THE PRODUCTS OF THE MDR1A AND MDR1B GENES FROM MULTIDRUG RESISTANT MURINE CELLS HAVE SIMILAR DEGRADATION RATES

被引：24

作者：

COHEN, D ^{[1
]}

YANG, CPH ^{[1
]}

HORWITZ, SB ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT CELL BIOL,BRONX,NY 10461

来源：

LIFE SCIENCES | 1990年 / 46卷 / 07期

关键词：

D O I：

10.1016/0024-3205(90)90004-B

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Two vinblastine-resistant sublines of the murine macrophage-like cell line J774.2, J7.V1-1 and J7.V3-1, overproduce unique forms of P-glycoprotein that are encoded by distinct mdr genes, mdrlb and mdrla, respectively. Degradation rates of the two P-glycoprotein isoforms were measured by immunoprecipitation of P-glycoprotein. The half-life of immunoprecipitable P-glycoprotein from J7.V1-1 cells was 16.8 ± 0.5 hours and from J7.V3-1 cells, 17.4 ± 0.5 hours. This rate was not influenced by the presence of vinblastine in the growth medium. The data indicate that P-glycoproteins derived from distinct genes have similar degradation rates. © 1990.

引用

页码：489 / 495

页数：7

共 14 条

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