MULTIPLE INTERCELLULAR SIGNALING SYSTEMS CONTROL THE DEVELOPMENT OF THE CAENORHABDITIS-ELEGANS VULVA

被引：229

作者：

HORVITZ, HR ^{[1
]}

STERNBERG, PW ^{[1
]}

机构：

[1] CALTECH,HOWARD HUGHES MED INST,DIV BIOL,PASADENA,CA 91125

来源：

NATURE | 1991年 / 351卷 / 6327期

关键词：

D O I：

10.1038/351535a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Developmental, genetic and molecular studies indicate that multiple intercellular signalling systems interact to specify the types and spatial patterns of cells generated during the formation of the vulva of the nematode Caenorhabditis elegans. Two classes of evolutionarily conserved transmembrane receptors and a Ras protein function in these signalling systems. The biology of vulval development provides a framework for understanding how cell interactions control the development of animals as diverse as nematodes, insects and mammals.

引用

页码：535 / 541

页数：7

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