PROLONGED SHELF STABILITY AND BIOCOMPATIBILITY OF A CONCENTRATED INJECTABLE FLUOROCARBON EMULSION

A four-year-old 100%w/v concentrated emulsion of Perfluorooctylbromide (PFOB, perflubron) stored at 5-degrees-C, when submitted to the close-to-total exchange-perfusion test in conscious rats (Hct 3-5%) still resulted in 75% survival. Particle size and size distribution, viscosity, pH were still in the acceptable range.