DETERMINING THE SOLUBILITY AND CRYSTAL FORM OF CLENBUTEROL IN THIN-FILMS OF EUDRAGIT NE30D

被引：8

作者：

GOPFERICH, A ^{[1
]}

LEE, G ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST PHARMAZEUT TECHNOL & BIOPHARM,NEUENHEIMER FELD 366,W-6900 HEIDELBERG,GERMANY

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 03期

关键词：

D O I：

10.3109/03639049209043702

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The solubility of the drug clenbuterol in thin films of surfactant-free Eudragit NE30D has been measured. Light microscopy and differential scanning calorimetry were supplemented by a technique based on measurement of the rate of drug release from the films. The clenbuterol crystals had the form of a fractal, as could be shown by a computer simulation of diffusion-controlled aggregation.

引用

页码：319 / 331

页数：13

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