CHROMOSOME 10 ALLELIC LOSS IN MALIGNANT-MELANOMA

被引：88

作者：

ISSHIKI, K

ELDER, DE

GUERRY, D

LINNENBACH, AJ

机构：

[1] WISTAR INST ANAT & BIOL,36TH & SPRUCE ST,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104

[3] UNIV PENN,CTR CANC,PHILADELPHIA,PA 19104

[4] UNIV PENN,DEPT MED,DIV HEMATOL ONCOL,PHILADELPHIA,PA 19104

来源：

GENES CHROMOSOMES & CANCER | 1993年 / 8卷 / 03期

关键词：

D O I：

10.1002/gcc.2870080307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The involvement of tumor suppressor genes in the progression of melanoma has been suggested by the frequent deletion of specific regions of the genome in melanoma. In this study, a panel of 18 surgically removed melanomas from 15 patients was analyzed for loss of heterozygosity (LOH) at 10 polymorphic loci on chromosome 10. LOH was observed in 7 (50%) of 14 informative patients. LOH data suggested that melanomas from 5 patients had lost entire copies of chromosome 10, and that melanomas from 2 patients had lost copies of 10q. In contrast, LOH was not observed on chromosome 15, 20, or 21. These results are consistent with previous cytogenetic observations and provide indirect evidence that there is a tumor suppressor gene on the long arm of chromosome 10 which is relevant to melanoma development. (C) 1993 Wiley-Liss, Inc.

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页码：178 / 184

页数：7

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