ARENASTATIN-A, A POTENT CYTOTOXIC DEPSIPEPTIDE FROM THE OKINAWAN MARINE SPONGE DYSIDEA-ARENARIA

被引：70

作者：

KOBAYASHI, M ^{[1
]}

AOKI, SJ ^{[1
]}

OHYABU, N ^{[1
]}

KUROSU, M ^{[1
]}

WANG, WQ ^{[1
]}

KITAGAWA, I ^{[1
]}

机构：

[1] OSAKA UNIV, FAC PHARMACEUT SCI, SUITA, OSAKA 565, JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)78398-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arenastatin A (1) has been isolated from the Okinawan marine sponge Dysidea arenaria and the chemical structure including parts of the absolute configurations elucidated. Arenastatin A (I) is a cyclic didepsipeptide and exhibited extremely potent cytotoxicity against KB cells at IC50 5 pg/ml.

引用

页码：7969 / 7972

页数：4

共 7 条

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