THE 1ST ENANTIOSELECTIVE SYNTHESIS OF FORTAMINE, THE 1,4-DIAMINOCYCLITOL MOIETY OF FORTIMICIN-A, BY CHEMICOENZYMATIC APPROACH

被引：57

作者：

KOBAYASHI, S

KAMIYAMA, K

OHNO, M

机构：

[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 04期

关键词：

D O I：

10.1021/jo00291a014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fortamine, the 1,4-diaminocyclitol moiety of deoxyaminoglycoside antibiotic fortimicin A, has been synthesized enantioselectively for the first time from 1-methyl (1S,2R)-l,2-cyclohex-4-enedicarboxylate in 22% overall yield. © 1990, American Chemical Society. All rights reserved.

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页码：1169 / 1177

页数：9

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