A FACILE SYNTHESIS OF 3-ARYL-4-PYRAZOLEACETIC ACIDS AND OF THEIR 4,5-DIHYDRO DERIVATIVES

被引：4

作者：

CURZU, MM

PINNA, GA

BARLOCCO, D

CIGNARELLA, G

机构：

[1] UNIV MILANO,IST CHIM FARMACEUT & TOSSICOL,VIALE ABRUZZI 42,I-20131 MILAN,ITALY

[2] UNIV SASSARI,INST CHIM FARMACEUT,I-07100 SASSARI,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 02期

关键词：

D O I：

10.1002/jhet.5570270217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N‐1‐Unsubstituted‐3‐aryl‐4‐pyrazoleacetic acids and their 4,5‐dihydro derivatives can conveniently be prepared by cyclization of 3‐benzoyl‐3‐butenoic acids with hydrazine hydrate in acetic acid and subsequent treatment with bromine in acetic acid or, respectively, with diluted mineral acids. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：205 / 208

页数：4

共 10 条

[1] ACHENBACH H, 1973, LIEBIGS ANN CHEM, V11, P1919
[2] USE OF ALPHA-(ARYL)-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) IN 1,4-ADDITIONS TO ALPHA,BETA-UNSATURATED ESTERS AND NITRILES - VERSATILE SYNTHETIC ROUTE TO 6-ARYL-3(2H)PYRIDAZINONES
ALBRIGHT, JD
MCEVOY, FJ
MORAN, DB
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (06) : 881 - 892
[3] BARLOCCO D, 1987, FARMACO, V42, P585
[4] BEHR LC, 1980, CHEM HETEROCYCLIC CO, V22, P825
[5] CIGNARELLA G, 1989, SYNTHESIS-STUTTGART, P320
[6] CIGNARELLA G, 1980, SYNTHESIS-STUTTGART, P825
[7] 6-PHENYL-4,5-DIHYDRO-3(H-2)-PYRIDAZINONES - SERIES OF HYPOTENSIVE AGENTS
CURRAN, WV
ROSS, A
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) : 273 - 281
[8] KOHL B, 1983, Patent No. 94555
[9] Rainer G., 1979, [No title captured], Patent No. [US 4146721 A, 4146721]
[10] VONRIEDEL R, 1981, ARZNEIM FORSCH DRUG, V31, P655

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