MAPPING OF THE GENE-TCF2 CODING FOR THE TRANSCRIPTION FACTOR LFB3 TO HUMAN CHROMOSOME-17 BY POLYMERASE CHAIN-REACTION

被引：18

作者：

ABBOTT, C

PIAGGIO, G

AMMENDOLA, R

SOLOMON, E

POVEY, S

GOUNARI, F

DESIMONE, V

CORTESE, R

机构：

[1] IMPERIAL CANC RES FUND,SOMAT CELL GENET LAB,LONDON WC2A 3PX,ENGLAND

[2] UNIV LONDON UNIV COLL,MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND

[3] EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1990年 / 8卷 / 01期

关键词：

D O I：

10.1016/0888-7543(90)90239-Q

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A human clone corresponding to the gene for the DNA-binding factor LFB3, a protein highly homologous to the liver-specific transcription factor LFB1, has been isolated and partially sequenced. This gene is designated TCF2. Oligonucleotide primers have been designed for LFB3 and used to amplify specifically the human gene in human/rodent somatic cell hybrids using the polymerase chain reaction. By this means, the human LFB3 gene has been mapped to the long arm of chromosome 17, between the centromere and the APL breakpoint. © 1990.

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页码：165 / 167

页数：3

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