BUPRENORPHINE VERSUS DOMPERIDONE IN CHEMOTHERAPY-INDUCED EMESIS - A PILOT-STUDY

被引：2

作者：

DULLEMONDWESTLAND, AC

NEIJT, JP

NORTIER, JWR

SITSEN, JMA

机构：

来源：

RADIOTHERAPY AND ONCOLOGY | 1986年 / 6卷 / 02期

关键词：

D O I：

10.1016/S0167-8140(86)80019-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A randomized double-blind cross-over study was performed to evaluate the possible anti-emetic effect of the partial opiate antagonist buprenorphine in comparison to domperidone in chemotherapy-induced nausea and vomiting. Emesis was of significantly shorter duration on domperidone treatment. Most patients preferred domperidone, mainly due to adverse side-effects of buprenorphine. Nevertheless, emesis in buprenorphine treatment was less disabling. Therefore, it might be useful to search for new alternatives in this group of drugs or to use them in a combination regimen of anti-emetic agents.

引用

页码：127 / 133

页数：7