THE EFFECT OF LOVASTATIN ON VERY LOW-DENSITY-LIPOPROTEIN APOLIPOPROTEIN-B PRODUCTION BY THE LIVER IN FAMILIAL COMBINED HYPERLIPEMIA

被引:17
作者
CORTNER, JA
BENNETT, MJ
LE, NA
COATES, PM
机构
[1] UNIV PENN,DEPT PEDIAT,PHILADELPHIA,PA 19104
[2] BAYLOR UNIV,MED CTR,CTR METAB DIS,DALLAS,TX
[3] EMORY UNIV,DEPT MED,DIV ARTERIOSCLEROSIS & LIPID METAB,ATLANTA,GA 30322
关键词
D O I
10.1007/BF00711326
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Overproduction of very low-density lipoprotein apolipoprotein B by the liver is a metabolic marker for familial combined hyperlipidaemia, a common inherited disorder of lipoprotein metabolism. Four subjects with familial combined hyperlipidaemia had rates of apolipoprotein B production which were 2-7 times normal, using a protocol in which [N-15]glycine was used to label newly synthesized hepatic proteins. Following 4-6 months of therapy with lovastatin, very low-density lipoprotein apolipoprotein B production in all four subjects had returned to the normal range. This demonstrates that lovastatin, an inhibitor of cholesterol biosynthesis, acts also to reduce the apparent production rate of apolipoprotein B by the liver.
引用
收藏
页码:127 / 134
页数:8
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