BRUCEANOLS D, E, AND F - 3 NEW CYTOTOXIC QUASSINOIDS FROM BRUCEA-ANTIDYSENTERICA

被引：27

作者：

IMAMURA, K

FUKAMIYA, N

OKANO, M

TAGAHARA, K

LEE, KH

机构：

[1] HIROSHIMA UNIV, FAC INTEGRATED ARTS & SCI, INTERDISCIPLINARY STUDIES NAT ENVIRONM, HIROSHIMA 730, JAPAN

[2] KOBE WOMENS COLL PHARM, FAC PHARMACEUT SCI, KOBE 658, JAPAN

[3] UNIV N CAROLINA, SCH PHARM, DIV MED CHEM & NAT PROD, NAT PROD LAB, CHAPEL HILL, NC 27599 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 12期

关键词：

D O I：

10.1021/np50102a010

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Three new quassinoids, bruceanols D [1], E [2], and F [3], were isolated from Brucea antidysenterica, and their structures were elucidated by spectral evidence and chemical transformation All of these compounds exhibited cytotoxicity against five human tumor cell lines, malignant melanoma (RPMI-7951), lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of the nasopharynx (KB), and medulloblastoma (TE-671), and against murine lymphocytic leukemia (P-388).

引用

页码：2091 / 2097

页数：7

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