SYNTHESIS AND EVALUATION OF 19-AZAANDROSTENEDIONE AND 19-AMINOANDROSTENEDIONE ANALOGS AS POTENTIAL AROMATASE INHIBITORS

被引:23
作者
LOVETT, JA
DARBY, MV
COUNSELL, RE
机构
[1] UNIV MICHIGAN,SCH MED,DEPT PHARMACOL,ANN ARBOR,MI 48109
[2] UNIV MICHIGAN,SCH MED,INTERDEPT PROGRAM MED CHEM,ANN ARBOR,MI 48109
关键词
D O I
10.1021/jm00372a005
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:734 / 740
页数:7
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共 62 条
[1]   INHIBITION OF ANDROGEN AROMATIZATION IN HUMAN-BREAST CANCER [J].
ABULHAJJ, YJ .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1980, 13 (12) :1395-1400
[2]   UBER STEROIDE UND SEXUALHORMONE .227. DIE FRAGMENTIERUNG EINWERTIGER ALKOHOLE MIT BLEI(IV)-ACETAT [J].
AMOROSA, M ;
MIHAILOVIC, ML ;
CAGLIOTI, L ;
JEGER, O ;
CAINELLI, G ;
SCHAFFNER, K ;
WEHRLI, H ;
KELLER, J ;
ARIGONI, D ;
IMMER, H .
HELVETICA CHIMICA ACTA, 1962, 45 (07) :2674-&
[3]   ACTIVE-SITE-DIRECTED INACTIVATION OF AROMATASE FROM HUMAN PLACENTAL MICROSOMES BY BROMINATED ANDROGEN DERIVATIVES [J].
BELLINO, FL ;
GILANI, SSH ;
ENG, SS ;
OSAWA, Y ;
DUAX, WL .
BIOCHEMISTRY, 1976, 15 (21) :4730-4736
[4]   C-13 NMR-STUDIES .69. C-13 NMR-SPECTRA OF STEROIDS - SURVEY AND COMMENTARY [J].
BLUNT, JW ;
STOTHERS, JB .
ORGANIC MAGNETIC RESONANCE, 1977, 9 (08) :439-464
[5]   CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].
BORCH, RF ;
BERNSTEIN, MD ;
DURST, HD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) :2897-+
[6]   STEROIDS .202. A NEW ROUTE TO 19-NOR STEROIDS [J].
BOWERS, A ;
HALPERN, O ;
EDWARDS, JA ;
VILLOTTI, R ;
DENOT, E .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (16) :3204-&
[7]   INACTIVATION OF AROMATASE INVITRO BY 4-HYDROXY-4-ANDROSTENE-3, 17-DIONE AND 4-ACETOXY-4-ANDROSTENE-3, 17-DIONE AND SUSTAINED EFFECTS INVIVO [J].
BRODIE, AMH ;
GARRETT, WM ;
HENDRICKSON, JR ;
TSAIMORRIS, CH ;
MARCOTTE, PA ;
ROBINSON, CH .
STEROIDS, 1981, 38 (06) :693-702
[8]   AROMATASE INHIBITORS .4. REGRESSION OF HORMONE-DEPENDENT, MAMMARY-TUMORS IN THE RAT WITH 4-ACETOXY-4-ANDROSTENE-3,17-DIONE [J].
BRODIE, AMH ;
MARSH, D ;
BRODIE, HJ .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1979, 10 (04) :423-429
[9]   AROMATASE INHIBITORS AND THEIR USE IN CONTROLLING ESTROGEN-DEPENDENT PROCESSES [J].
BRODIE, AMH ;
MARSH, DA ;
WU, JT ;
BRODIE, HJ .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1979, 11 (01) :107-112
[10]   AROMATASE INHIBITORS .3. STUDIES ON ANTI-FERTILITY EFFECT OF 4-ACETOXY-4-ANDROSTENE-3,17-DIONE [J].
BRODIE, AMH ;
WU, JT ;
MARSH, DA ;
BRODIE, HJ .
BIOLOGY OF REPRODUCTION, 1978, 18 (03) :365-370