HEPATIC MICROSOMAL ENZYMES IN MAN AND RAT - INDUCTION AND INHIBITION BY ETHANOL

被引：341

作者：

RUBIN, E

LIEBER, CS

机构：

[1] Department of Pathology, Mount Sinai School of Medicine, City University of New York, New York

[2] Section of Liver Disease and Nutrition, Bronx Veterans Administration Hospital

来源：

SCIENCE | 1968年 / 162卷 / 3854期

关键词：

D O I：

10.1126/science.162.3854.690

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.

引用

页码：690 / &

共 10 条

[1]

CONNEY AH, 1967, PHARMACOL REV, V19, P317

[2]

FOUTS JR, 1957, J PHARMACOL EXP THER, V119, P197

[3] ACTIVATION AND INHIBITION OF MICROSOMAL HYDROXYLATION BY ETHYL ISOCYANIDE [J].