PREFERENTIAL MUTAGENESIS AT G.C BASE-PAIRS BY THE ANTI-3,4-DIHYDRODIOL 1,2-EPOXIDE OF 7-METHYLBENZ[A]ANTHRACENE

被引：22

作者：

BIGGER, CAH

FLICKINGER, DJ

STJOHN, J

HARVEY, RG

DIPPLE, A

机构：

[1] NCI, FREDERICK CANC RES FACIL, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, FREDERICK, MD 21701 USA

[2] UNIV CHICAGO, BEN MAY INST, CHICAGO, IL 60637 USA

来源：

MOLECULAR CARCINOGENESIS | 1991年 / 4卷 / 03期

关键词：

MUTAGENIC SPECIFICITY; DIOL EPOXIDE; 7-METHYLBENZ[A]ANTHRACENE; SHUTTLE VECTOR;

D O I：

10.1002/mc.2940040303

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The racemic anti-dihydrodiol epoxide of 7-methylbenz[a]anthracene preferentially induced mutations at G.C base pairs in the pS189 shuttle vector. Mutations were not randomly distributed throughout the supF target gene, but were concentrated at five hotspots. The hotspots for this agent did not correspond exactly to those produced by any other dihydrodiol epoxide examined to date, indicating that dihydrodiol epoxide structure and reactivity play a major role in determining mutagenic hotspots.

引用

页码：176 / 179

页数：4

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