ESTROGEN INDUCTION OF HEPATOCELLULAR CARCINOMAS IN ARMENIAN HAMSTERS

被引：45

作者：

COE, JE ^{[1
]}

ISHAK, KG ^{[1
]}

ROSS, MJ ^{[1
]}

机构：

[1] ARMED FORCES INST PATHOL,WASHINGTON,DC 20306

来源：

HEPATOLOGY | 1990年 / 11卷 / 04期

关键词：

D O I：

10.1002/hep.1840110408

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver tumors were found in most Armenian hamsters Cricetulus migratorius injected with on 15‐mg pellet of diethylstilbestrol. The tumors were detectable as early as 1.5 mo after diethylstilbestrol administration and were usually present as multiple nodules that progressively increased in size. Histologically, the multicentric neoplasms were all hepatocellular carcinomas of varied degrees of differentiation and frequently (42.8%) contained Mallory bodies; preneoplastic lesions were not observed. This hepatocellular carcinoma hamster model is unique because estrogen alone without any other known mutagen is responsible for induction of hepatocellular carcinoma.(HEPATOLOGY 1990; 11:570:577.) Copyright © 1990 American Association for the Study of Liver Diseases

引用

页码：570 / 577

页数：8

共 39 条

[1] PRENEOPLASTIC LESIONS AS END-POINTS IN CARCINOGENICITY TESTING .1. HEPATIC PRENEOPLASIA [J].