ENHANCEMENT OF PENTAZOCINE ANALGESIA BY CLONIDINE

被引：15

作者：

GORDON, NC

HELLER, PH

LEVINE, JD

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT ANAT,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT ORAL & MAXILLOFACIAL SURG,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,DIV NEUROSCI,SAN FRANCISCO,CA 94143

[5] KAISER PERMANENTE MED CTR,DEPT EMERGENCY MED,HAYWARD,CA

来源：

PAIN | 1992年 / 48卷 / 02期

关键词：

CLONIDINE; PENTAZOCINE; DENTAL POSTOPERATIVE PAIN; OPIATE ADRENERGIC INTERACTIONS;

D O I：

10.1016/0304-3959(92)90054-F

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain level when administered with intravenous placebo. When administered with pentazocine, clonidine caused a statistically significant increase in pentazocine analgesia. Comparison is made to other opiate-adrenergic interactions and possible mechanisms are discussed.

引用

页码：167 / 169

页数：3

共 17 条

[1]

CALCUTT CR, 1973, AGONIST ANTAGONIST A, P176

[2] DEXTROAMPHETAMINE WITH MORPHINE FOR TREATMENT OF POSTOPERATIVE PAIN [J].