ROLE OF ACID TOLERANCE RESPONSE GENES IN SALMONELLA-TYPHIMURIUM VIRULENCE

被引：52

作者：

GARCIADELPORTILLO, F

FOSTER, JW

FINLAY, BB

机构：

[1] UNIV BRITISH COLUMBIA, BIOTECHNOL LAB, 6174 UNIV BLVD, VANCOUVER V6T 1Z3, BC, CANADA

[2] UNIV BRITISH COLUMBIA, DEPT BIOCHEM, VANCOUVER V6T 1Z3, BC, CANADA

[3] UNIV SO ALABAMA, COLL MED, DEPT MICROBIOL, MOBILE, AL 36688 USA

[4] UNIV SO ALABAMA, COLL MED, DEPT IMMUNOL, MOBILE, AL 36688 USA

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 10期

关键词：

D O I：

10.1128/IAI.61.10.4489-4492.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The atp and fur genes are involved in the acid tolerance response of Salmonella typhimurium. An atp=Tn10 mutant was avirulent in the mouse typhoid model when assayed by oral and intraperitoneal routes. However, a fur mutant was completely virulent by the intraperitoneal route. No relevant differences in intracellular survival or invasion rates were observed for the two mutants in macrophages and epithelial cells. These data indicate that separate acid tolerance response genes may have different roles in S. typhimurium virulence.

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页码：4489 / 4492

页数：4

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