DETECTION OF M-BCR/ABL FUSION BY FLUORESCENCE IN-SITU HYBRIDIZATION (FISH) IN A CASE OF PH-NEGATIVE CML

被引：6

作者：

MOHAMED, AN ^{[1
]}

EBRAHIM, SAD ^{[1
]}

SARKAR, FH ^{[1
]}

UBERTI, J ^{[1
]}

WOLMAN, SR ^{[1
]}

机构：

[1] WAYNE STATE UNIV,HARPER HOSP,DEPT PATHOL,CYTOGENET LAB,DETROIT,MI 48201

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 80卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)00118-U

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A balanced reciprocal translocation, t(6;9)(p21;q34), was identified in a female patient diagnosed with chronic myeloid leukemia (CML). Both homologs of chromosome 22 were of normal length and morphology. Southern blotting revealed a bcr rearrangement with BglII and HindIII. Two signals for the abl probe were demonstrated by fluorescence in situ hybridization (FISH), one on the normal chromosome 9 and the second on a chromosome 22. Thus, molecular rearrangement of bcr resulted from insertion of an abl gene within the bcr region despite absence of a Ph chromosome.

引用

页码：60 / 62

页数：3

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