CELL-ADHESION MOLECULES AND THE KIDNEY

被引：38

作者：

RABB, HAA

机构：

[1] Division of Nephrology and Hypertension, University of South Florida, James A. Haley Veterans Hospital, Tampa, Florida

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1994年 / 23卷 / 02期

关键词：

CELL ADHESION MOLECULES; KIDNEY;

D O I：

10.1016/S0272-6386(12)80965-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cell adhesion molecules (CAMs) have been implicated in various biologic processes, including morphogenesis, immune response, and thrombosis. There are four major groups: integrins, cadherins, immunoglobulin superfamily members, and selectins. Certain CAMs are differentially expressed in the developing, normal, and cancerous kidney. Other CAMs are altered in glomerulonephritis and transplant rejection. Preliminary studies suggest that blocking CAMs can attenuate tissue damage in human transplant rejection and animal models of glomerulonephritis. The study of CAMs in relation to the kidney is providing further insight into the normal and diseased kidney, and may lead to feasible new treatments for patients with renal diseases. © 1994, National Kidney Foundation. All rights reserved. All rights reserved.

引用

页码：155 / 166

页数：12

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