ASYMMETRIC-SYNTHESIS OF ENANTIOMERICALLY PURE 4'-FLUOROALKYL-2',3'-DIDEOXY NUCLEOSIDES

被引：9

作者：

BRAVO, P ^{[1
]}

MELE, A ^{[1
]}

SALANI, G ^{[1
]}

VIANI, F ^{[1
]}

机构：

[1] POLITECN MILAN,DIPARTIMENTO CHIM,CNR,CTR STUDIO SUNTANZE ORGAN NAT,I-20131 MILAN,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)80569-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Elaboration of 2-(fluoromethyl)-2-[(4-methylphenylsulphinyl)methyl] oxirane (5), deriving from p-tolylmethyl sulphoxide (2), ethyl fluoroacetate (3) and diazomethane, to 4'-fluoromethyl lactol (10) followed by condensation with the activated thymine and reductive debenzylation allowed the obtainment of 4'-fluoromethyl-2',3'-dideoxythymidine (1).

引用

页码：1577 / 1580

页数：4

共 26 条

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[7] ASYMMETRIC-SYNTHESIS AND STRUCTURAL-ANALYSIS OF 5-O-BENZOYL-2,3-DIDEOXY-3-FLUORO-ALPHA,BETA-D-RIBOFURANOSE AND 5-O-BENZOYL-2,3-DIDEOXY-3-FLUORO-ALPHA,BETA-D-XYLOFURANOSE FROM HOMOCHIRAL 1-FLUORO-3-SULFINYLACETONE
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[9] BRAVO P, 1993, IL FARMACO, V48, P1113
[10] CHU C K, 1991, Journal of Organic Chemistry, V56, P6503, DOI 10.1021/jo00023a010

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