MEMBRANE FLUCTUATIONS IN ERYTHROCYTES ARE LINKED TO MGATP-DEPENDENT DYNAMIC ASSEMBLY OF THE MEMBRANE SKELETON

被引：101

作者：

LEVIN, S ^{[1
]}

KORENSTEIN, R ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER FAC MED,DEPT PHYSIOL & PHARMACOL,IL-69978 TEL AVIV,ISRAEL

来源：

BIOPHYSICAL JOURNAL | 1991年 / 60卷 / 03期

关键词：

D O I：

10.1016/S0006-3495(91)82104-X

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The observation of low-frequency fluctuations of the cell membrane in erythrocytes and in several nucleated cells suggests that this phenomenon may be a general property of the living cell. A study of these fluctuations in human erythrocytes and its ghosts has now been carried out using a novel optical method based on point dark field microscopy. We have demonstrated that the reestablishment of membrane fluctuations in erythrocyte ghosts is dependent on MgATP but does not necessarily require the restoration of the biconcave shape. The results imply that the dominant component of membrane fluctuations are metabolically dependent and suggest the existence of a dynamic mechano-chemical coupling within the membrane skeleton network induced by MgATP.

引用

页码：733 / 737

页数：5

共 24 条

[1] THE SPECTRIN-ACTIN JUNCTION OF ERYTHROCYTE-MEMBRANE SKELETONS [J].

BENNETT, V .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 988 (01) :107-121

[2] FREQUENCY SPECTRUM OF FLICKER PHENOMENON IN ERYTHROCYTES [J].

BROCHARD, F ;

LENNON, JF .

JOURNAL DE PHYSIQUE, 1975, 36 (11) :1035-1047

[3]

BULL BS, 1989, RED BLOOD CELL MEMBR, P401

[4] SYNCHRONOUS OSCILLATIONS IN MICROTUBULE POLYMERIZATION [J].

CARLIER, MF ;

MELKI, R ;

PANTALONI, D ;

HILL, TL ;

CHEN, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5257-5261

[5]

ELSON EL, 1988, ANNU REV BIOPHYS BIO, V17, P397

[6] THERMAL-MECHANICAL FLUCTUATIONS ENHANCE REPULSION BETWEEN BIOMOLECULAR LAYERS [J].

EVANS, EA ;

PARSEGIAN, VA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (19) :7132-7136

[7] VARIATION OF FREQUENCY-SPECTRUM OF THE ERYTHROCYTE FLICKERING CAUSED BY AGING, OSMOLARITY, TEMPERATURE AND PATHOLOGICAL-CHANGES [J].

FRICKE, K ;

SACKMANN, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 803 (03) :145-152

[8]

FRICKE K, 1986, EUR BIOPHYS J BIOPHY, V14, P67, DOI 10.1007/BF00263063

[9] STRETCH-ACTIVATED SINGLE ION CHANNEL CURRENTS IN TISSUE-CULTURED EMBRYONIC CHICK SKELETAL-MUSCLE [J].

GUHARAY, F ;

SACHS, F .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 352 (JUL) :685-701

[10] ORDER AND CHAOS IN BIOCHEMISTRY [J].

HESS, B ;

MARKUS, M .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (02) :45-48

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