CEREBELLAR LONG-TERM POTENTIATION UNDER SUPPRESSED POSTSYNAPTIC CA2+ ACTIVITY

被引:58
作者
SHIBUKI, K
OKADA, D
机构
[1] Laboratory for Neural Networks, Saitama, 351-01, Riken Wako
关键词
LONG-TERM DEPRESSION; LONG-TERM POTENTIATION; CYCLIC GMP; POSTSYNAPTIC CA2+ ACTIVITY; NITRIC OXIDE; PURKINJE CELLS; CEREBELLUM;
D O I
10.1097/00001756-199203000-00003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
TO study the roles of postsynaptic Ca2+ activity in cerebellar synaptic plasticity, we used a patch-recording technique in Purkinje cell dendrites. While the combination of parallel fibre stimulation and 8-bromo cyclic guanosine monophosphate (Br-cGMP) application produced long-term depression (LTD) of the parallel fibre/Purkinje cell transmission, the same stimuli evoked long-term potentiation (LTP) during postsynaptic injection of Ethyl-eneglycol-bis-(beta-amino-ethylether)-N, N, N', N'-tetraacetate (EGTA). Furthermore, in the presence of alpha-aminobutyric acid (GABA), parallel fibre stimulation plus Br-cGMP produced LTP of extracellular K+ increases following parallel fibre stimulation. These results suggest that postsynaptic Ca2+ activity in Purkinje cells is negatively correlated to the direction of plastic changes and that the Ca2+ changes and cGMP play distinct roles in cerebellar synaptic plasticity.
引用
收藏
页码:231 / 234
页数:4
相关论文
共 22 条
[1]   DIFFERENT VOLTAGE-DEPENDENT THRESHOLDS FOR INDUCING LONG-TERM DEPRESSION AND LONG-TERM POTENTIATION IN SLICES OF RAT VISUAL-CORTEX [J].
ARTOLA, A ;
BROCHER, S ;
SINGER, W .
NATURE, 1990, 347 (6288) :69-72
[2]   CLIMBING FIBER ACTIVATION AND 3',5'-CYCLIC GUANOSINE MONOPHOSPHATE (CGMP) CONTENT IN CORTEX AND DEEP NUCLEI OF CEREBELLUM [J].
BIGGIO, G ;
GUIDOTTI, A .
BRAIN RESEARCH, 1976, 107 (02) :365-373
[3]   WHOLE CELL RECORDING FROM NEURONS IN SLICES OF REPTILIAN AND MAMMALIAN CEREBRAL-CORTEX [J].
BLANTON, MG ;
LOTURCO, JJ ;
KRIEGSTEIN, AR .
JOURNAL OF NEUROSCIENCE METHODS, 1989, 30 (03) :203-210
[4]   LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].
BREDT, DS ;
HWANG, PM ;
SNYDER, SH .
NATURE, 1990, 347 (6295) :768-770
[5]   ACTIVATION OF PROTEIN KINASE-C INDUCES A LONG-TERM DEPRESSION OF GLUTAMATE SENSITIVITY OF CEREBELLAR PURKINJE-CELLS - AN INVITRO STUDY [J].
CREPEL, F ;
KRUPA, M .
BRAIN RESEARCH, 1988, 458 (02) :397-401
[6]  
Crepel F, 1990, Neuroreport, V1, P133, DOI 10.1097/00001756-199010000-00013
[7]   NANOMOLAR N-G-NITROARGININE INHIBITS NMDA-INDUCED CYCLIC-GMP FORMATION IN RAT CEREBELLUM [J].
EAST, SJ ;
GARTHWAITE, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 184 (2-3) :311-313
[8]   LONG-TERM DEPRESSION OF PARALLEL FIBER SYNAPSES FOLLOWING STIMULATION OF CLIMBING FIBERS [J].
EKEROT, CF ;
KANO, M .
BRAIN RESEARCH, 1985, 342 (02) :357-360
[9]   EFFECTS OF POSTSYNAPTIC DEPOLARIZATION IN THE INDUCTION OF SYNAPTIC DEPRESSION BETWEEN A GRANULE CELL AND A PURKINJE-CELL IN RAT CEREBELLAR CULTURE [J].
HIRANO, T .
NEUROSCIENCE LETTERS, 1990, 119 (02) :145-147
[10]   CLIMBING FIBER INDUCED DEPRESSION OF BOTH MOSSY FIBER RESPONSIVENESS AND GLUTAMATE SENSITIVITY OF CEREBELLAR PURKINJE-CELLS [J].
ITO, M ;
SAKURAI, M ;
TONGROACH, P .
JOURNAL OF PHYSIOLOGY-LONDON, 1982, 324 (MAR) :113-134