AN ACYLIMINIUM ION ROUTE TO CIS AND TRANS ANTI-PHE-GLY DIPEPTIDE MIMETICS

被引：37

作者：

FLYNN, GA

BURKHOLDER, TP

HUBER, EW

BEY, P

机构：

[1] Marion Merrell Dow Research Institute, Cincinnati, OH 45215

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80814-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of two series of constrained mimetics of the dipeptide phenylalanyl-glycine oriented in the "anti" conformation (X1 = 180-degrees) are described. These benzolactams differ about the geometry of the internal amide bond (omega-1 = 0-degrees or 180-degrees). Solution NMR studies support specific conformational assignments for these mimetics.

引用

页码：309 / 312

页数：4

共 10 条

[1]

BENISHAI D, 1977, TETRAHEDRON, V33, P881

[2]

BENISHAI D, 1988, 20TH P EUR PEP S

[3] THE CONVERSION OF A DIAZOLACTAM TO AN ALPHA-METHYLENELACTAM - AN ENTRANCE TO NEW CONFORMATIONALLY RESTRICTED INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME [J].