VITILIGO IS ASSOCIATED WITH A SIGNIFICANT INCREASE IN HLA-A30, CW6 AND DQW3 AND A DECREASE IN C4AQO IN NORTHERN ITALIAN PATIENTS

被引：50

作者：

ORECCHIA, G ^{[1
]}

PERFETTI, L ^{[1
]}

MALAGOLI, P ^{[1
]}

BORGHINI, F ^{[1
]}

KIPERVARG, Y ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,NEW HAVEN,CT 06510

来源：

DERMATOLOGY | 1992年 / 185卷 / 02期

关键词：

VITILIGO; HUMAN LEUKOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX; COMPLEMENT;

D O I：

10.1159/000247426

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DQ) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, p(c) = 0.0144), Cw6 (p(c) = 0.0189), DQw3 (p(c) < 0.0003) and a significant decrease in C4AQ0 (p(c) = 0.003). Nonfamilial vitiligo is marked by increases in HLA-A30 and DQw3. Extensive vitiligo is marked by increases in HLA-A30 and Cw6. These findings suggest that immunogenetic mechanisms may be responsible for vitiligo and that unique HLA phenotypes may influence the expression of vitiligo in this population.

引用

页码：123 / 127

页数：5

共 29 条

[1] GENETIC POLYMORPHISM IN HUMAN GLYCINE-RICH BETA-GLYCOPROTEIN [J].