IN-SITU HYBRIDIZATION LOCALIZATION OF THE NA+ CHANNEL BETA-1 SUBUNIT MESSENGER-RNA IN RAT CNS NEURONS

被引：23

作者：

OH, YS

SASHIHARA, S

WAXMAN, SG

机构：

[1] YALE UNIV,SCH MED,DEPT NEUROL,NEW HAVEN,CT 06510

[2] VET ADM MED CTR,NEUROSCI RES CTR,W HAVEN,CT 06516

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

关键词：

ION CHANNEL; HIPPOCAMPUS; CEREBELLUM; SPINAL CORD;

D O I：

10.1016/0304-3940(94)90885-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Localization of Na+ channel beta 1 subunit (Na beta 1) mRNA was examined in adult rat hippocampus, cerebellum and spinal cord by in situ hybridization histochemistry. In hippocampus, Na beta 1 mRNA was strongly expressed by CA3 followed by CA1 pyramidal cells and dentate granule cells. In cerebellum, strong Na beta 1 mRNA expression was observed in Purkinje cells and moderate expression in granule cells and scattered cells of the molecular layer. In spinal cord, neurons in gray matter exhibited moderate to strong expression of Na beta 1 mRNA. These results provide the first localization study of Na beta 1 mRNA in the CNS, demonstrating a differential expression in different neurons.

引用

页码：119 / 122

页数：4

共 15 条

[1] DIFFERENTIAL REGULATION OF 3 SODIUM-CHANNEL MESSENGER-RNAS IN THE RAT CENTRAL NERVOUS-SYSTEM DURING DEVELOPMENT [J].