APOPTOSIS INDUCED BY HIGH-LET AND LOW-LET RADIATIONS

被引：50

作者：

HENDRY, JH ^{[1
]}

POTTEN, CS ^{[1
]}

MERRITT, A ^{[1
]}

机构：

[1] CHRISTIE HOSP NATL HLTH SERV TRUST,CRC,DEPT EPITHELIAL BIOL,PATERSON INST CANC RES,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

RADIATION AND ENVIRONMENTAL BIOPHYSICS | 1995年 / 34卷 / 01期

关键词：

D O I：

10.1007/BF01210548

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals.

引用

页码：59 / 62

页数：4

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