SENSORY EVOKED-POTENTIALS IN CREUTZFELDT-JAKOB DISEASE

被引:16
作者
AGUGLIA, U
FARNARIER, G
REGIS, H
OLIVERI, RL
QUATTRONE, A
机构
[1] UNIV REGGIO CALABRIA,IST SCI NEUROL,CATANZARO,ITALY
[2] CHU MARSEILLE,SERV EXPLORAT FONCTIONNELLE SYST NERVEUX,MARSEILLE,FRANCE
关键词
auditory brainstem responses; Creutzfeldt-Jakob disease; somatosensory evoked potentials; visual evoked potentials;
D O I
10.1159/000117335
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Eight patients presenting with intermediate or terminal evolution of Creutzfeldt-Jakob disease (CJD) were investigated by means of evoked potentials. Fifteen age-matched healthy subjects served as controls. The 8 patients had well-recognizable but simplified flash evoked potentials (FEPs) consisting of P1 and N2 waves followed by a single late positive (P2) deflection. Enlarged FEPS were found in 2 of the 8 patients. The somatosensory central conduction time was normal in 3 of 5 patients, and it resulted in upper normal limits or was moderately slowed in 2 patients. No enlarged somatosensory scalp potentials were recorded. Cortical somatosensory responses were characterized by an unrecognizable (4 patients) or delayed (2 patients) N33 wave. Brainstem auditory evoked responses, recorded in 6 patients, were normal. In CJD very important functional impairment of the sensory cortical areas is associated with absent or mild dysfunction of the subcortical sensory pathways.
引用
收藏
页码:157 / 161
页数:5
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