CROSSLINES A AND B AS CANDIDATES FOR THE FLUOROPHORES IN AGE-RELATED AND DIABETES-RELATED CROSS-LINKED PROTEINS, AND THEIR DIACETATES PRODUCED BY MAILLARD REACTION OF ALPHA-N-ACETYL-L-LYSINE WITH D-GLUCOSE

被引：80

作者：

NAKAMURA, K ^{[1
]}

HASEGAWA, T ^{[1
]}

FUKUNAGA, Y ^{[1
]}

IENAGA, K ^{[1
]}

机构：

[1] NIPPON ZOKI PHARMACEUT CO LTD,INST BIO ACT SCI,DEPT NAT PROD CHEM,KATO GUN,OSAKA 67314,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 14期

关键词：

D O I：

10.1039/c39920000992

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pair of novel fluorophores (N-diacetates of crosslines A and B), (3R,4S)-3,4-dihydroxy-5-[(1 S or 1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1,7-bis[6-(N-acetyl-L-norleucyl)]-1,2,3,4-tetrahydro-1,7-naphthyridinium chloride and its epimer, were isolated from the Maillard reaction mixture of alpha-N-acetyl-L-lysine and D-glucose, and their properties are similar to those of fluorophores in age- and diabetes-related cross-linked proteins, and a pair of homologues derived from n-pentylamine.

引用

页码：992 / 994

页数：3

共 9 条

[1] NONENZYMATIC GLYCOSYLATION AND THE PATHOGENESIS OF DIABETIC COMPLICATIONS [J].

BROWNLEE, M ;

VLASSARA, H ;

CERAMI, A .

ANNALS OF INTERNAL MEDICINE, 1984, 101 (04) :527-537

[2] FURTHER IDENTIFICATION OF NATURE AND LINKAGE OF CARBOHYDRATE IN HEMOGLOBIN-A1C [J].

BUNN, HF ;

HANEY, DN ;

GABBAY, KH ;

GALLOP, PM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 67 (01) :103-109

[3]

HAYASE F, 1989, J BIOL CHEM, V264, P3758

[4] ASSIGNMENT OF CARBONYL CARBONS AND SEQUENCE-ANALYSIS IN PEPTIDES BY HETERONUCLEAR SHIFT CORRELATION VIA SMALL COUPLING-CONSTANTS WITH BROAD-BAND DECOUPLING IN T1 (COLOC) [J].

KESSLER, H ;

GRIESINGER, C ;

ZARBOCK, J ;

LOOSLI, HR .

JOURNAL OF MAGNETIC RESONANCE, 1984, 57 (02) :331-336

[5]

Maillard LC, 1912, CR HEBD ACAD SCI, V154, P66

[6] ACCELERATED AGE-RELATED BROWNING OF HUMAN COLLAGEN IN DIABETES-MELLITUS [J].

MONNIER, VM ;

KOHN, RR ;

CERAMI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (02) :583-587

[7] NON-ENZYMATIC BROWNING INVIVO - POSSIBLE PROCESS FOR AGING OF LONG-LIVED PROTEINS [J].

MONNIER, VM ;

CERAMI, A .

SCIENCE, 1981, 211 (4481) :491-493

[8]

PENGOR S, 1984, P NATL ACAD SCI USA, V81, P2684

[9]

SELL DR, 1989, J BIOL CHEM, V264, P21597

← 1 →