COMPARISON OF PULMONARY AND HEPATIC GLUCURONIDATION AND SULFATION OF ETHANOL IN RAT AND RABBIT INVITRO

被引：17

作者：

MANAUTOU, JE ^{[1
]}

CARLSON, GP ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARM SCI,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907

来源：

XENOBIOTICA | 1992年 / 22卷 / 11期

关键词：

D O I：

10.3109/00498259209053159

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Pulmonary and hepatic UDP-glucuronyltransferase and sulphotransferase activities in subcellular fractions from rats and rabbits were determined, comparing ethanol with known substrates for these enzymes. 2. No ethyl glucuronide formation was detected with either hepatic or pulmonary microsomal incubations. 3. Chromatographic, autoradiographic and scintillation counting analysis indicated that ethanol is sulphated by rat and rabbit pulmonary cytosol, although this activity was approx. 2-6% of that in liver. 4. Rat hepatic and pulmonary sulphotransferase activities with beta-naphthol were approx. 13 and 60 times higher than with ethanol, respectively. 5. Rabbit hepatic and pulmonary sulphotransferase activities with both substrates were higher than those in rat.

引用

页码：1309 / 1319

页数：11

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