FAMILIAL SUDDEN-DEATH SYNDROME WITH AN ABNORMAL SIGNAL-AVERAGED ELECTROCARDIOGRAM AS A POTENTIAL MARKER

被引:3
作者
CHAMBERS, JW
DENES, P
DAHL, W
OLSON, DA
GALITA, D
OSBORN, MJ
TITUS, JL
机构
[1] ST PAUL RAMSEY MED CTR,CARDIOVASC SECT,ST PAUL,MN 55101
[2] UNITED HOSP,REGISTRY CARDIOVASC DIS,ST PAUL,MN
[3] MAYO CLIN,ROCHESTER,MN
关键词
D O I
10.1016/0002-8703(95)90447-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most familial sudden cardiac death syndromes are associated with structural heart disease or 12-lead electrocardiographic abnormalities. Additionally, the utility of signal-averaged electrocardiograms in patients with familial sudden death syndromes has not been examined. We studied a kindred with sudden death to determine whether they could be classified into any of the previously described syndromes and whether an abnormal signal-averaged electrocardiogram is a marker for this trait. Surviving family members had normal 12-lead electrocardiograms and echocardiograms. Two of the patients who died from ventricular arrhythmias had normal hearts on autopsy. Two surviving family members had a clinical history of arrhythmic events; both had abnormal signal-averaged electrocardiograms and Inducible ventricular arrhythmias during electrophysiologic studies. The other family members had normal signal-averaged electrocardiograms. This familial sudden death syndrome appears to be unique because the patients have anatomically normal hearts and normal 12-lead electrocardiograms. An abnormal signal-averaged electrocardiogram may be a marker for the sudden death trait.
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页码:318 / 323
页数:6
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