MOLECULAR RECOGNITION OF HORSE HEART APOMYOGLOBIN TO MONOPROPIONATE HEMIN - THERMODYNAMIC DETERMINATION OF 2 ORIENTATIONAL ISOMERS BY H-1-NMR SPECTRA

被引：11

作者：

HAYASHI, T ^{[1
]}

HITOMI, Y ^{[1
]}

SUZUKI, A ^{[1
]}

TAKIMURA, T ^{[1
]}

OGOSHI, H ^{[1
]}

机构：

[1] NAGAOKA COLL TECHNOL, DEPT MAT ENGN, NAGAOKA, NIIGATA 940, JAPAN

来源：

CHEMISTRY LETTERS | 1995年 / 10期

关键词：

D O I：

10.1246/cl.1995.911

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four synthetic hemins, 1,3,5,8-tetramethyl-2,4-diethyl-6,7-dipropionate hemin (1), 1,2,3,4-tetraethyl-5,6,8-trimethyl-7-propionate hemin (2), 1,3,5,6,8-pentamethyl-2,4-diethyl-7-propionate hemin (3) and 1,3,5,7,8-pentamethyl-2,4-diethyl-6-propionate hemin (4) were prepared and incorporated into apomyoglobin to clarify hydrophilic interaction of the hemin propionate with particular polar amino acid residues. Favorable orientation of hemin in protein is interpreted by thermodynamic study using H-1 NMR measurement.

引用

页码：911 / 912

页数：2

共 14 条

[1]

BRANTLEY RE, 1993, J BIOL CHEM, V268, P6995

[2] HIGH-RESOLUTION STUDY OF THE 3-DIMENSIONAL STRUCTURE OF HORSE HEART METMYOGLOBIN [J].

EVANS, SV ;

BRAYER, GD .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 213 (04) :885-897

[3]

EVANS SV, 1988, J BIOL CHEM, V263, P4263

[4] H-1-NMR STUDY OF THE ROLE OF INDIVIDUAL HEME PROPIONATES IN MODULATING STRUCTURAL AND DYNAMIC PROPERTIES OF THE HEME POCKET IN MYOGLOBIN [J].

HAUKSSON, JB ;

LAMAR, GN ;

PANDEY, RK ;

REZZANO, IN ;

SMITH, KM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (17) :6198-6205

[5] STUDIES ON RECONSTITUTED MYOGLOBINS AND HEMOGLOBINS .1. ROLE OF THE HEME SIDE-CHAINS IN THE OXYGENATION OF MYOGLOBIN [J].

KAWABE, K ;

IMAIZUMI, K ;

IMAI, K ;

TYUMA, I ;

OGOSHI, H ;

IWAHARA, T ;

YOSHIDA, Z .

JOURNAL OF BIOCHEMISTRY, 1982, 92 (06) :1703-1712

[6] PROTON NMR INVESTIGATION OF THE RATE AND MECHANISM OF HEME ROTATION IN SPERM WHALE MYOGLOBIN - EVIDENCE FOR INTRAMOLECULAR REORIENTATION ABOUT A HEME TWOFOLD AXIS [J].

LAMAR, GN ;

TOI, H ;

KRISHNAMOORTHI, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (21) :6395-6401

[7] INFLUENCE OF PROPIONATE SIDE-CHAINS ON THE EQUILIBRIUM HEME ORIENTATION IN SPERM WHALE MYOGLOBIN - HEME RESONANCE ASSIGNMENTS AND STRUCTURE DETERMINATION BY NUCLEAR OVERHAUSER EFFECT MEASUREMENTS [J].

LAMAR, GN ;

EMERSON, SD ;

LECOMTE, JTJ ;

PANDE, U ;

SMITH, KM ;

CRAIG, GW ;

KEHRES, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (18) :5568-5573

[8] INFLUENCE OF STERIC FACTORS ON OXYGEN BINDING .1. STUDIES ON 2,4-DIISOPROPYLDEUTEROHEME-MYOGLOBIN [J].

OGOSHI, H ;

KAWABE, K ;

MITACHI, S ;

YOSHIDA, ZI ;

IMAI, K ;

TYUMA, I .

BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 581 (02) :266-275

[9]

SANO S, 1979, PORPHYRINS, V7, pCH8

[10] BIS-MYOGLOBIN RECONSTITUTED WITH COVALENTLY BONDED SYMMETRIC HEMES [J].

SUZUKI, A ;

OKUDA, K ;

KAWAGOE, K ;

TOI, H ;

AOYAMA, Y ;

OGOSHI, H .

CHEMISTRY LETTERS, 1985, (08) :1169-1172

← 1 2 →