THE VANZ GENE OF TN1546 FROM ENTEROCOCCUS-FAECIUM BM4147 CONFERS RESISTANCE TO TEICOPLANIN

被引：129

作者：

ARTHUR, M ^{[1
]}

DEPARDIEU, F ^{[1
]}

MOLINAS, C ^{[1
]}

REYNOLDS, P ^{[1
]}

COURVALIN, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND

来源：

GENE | 1995年 / 154卷 / 01期

关键词：

CELL WALL; GLYCOPEPTIDE RESISTANCE; PEPTIDOGLYCAN; TRANSPOSON;

D O I：

10.1016/0378-1119(94)00851-I

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A five-gene cluster from Tn1546 confers resistance to the glycopeptide antibiotics vancomycin (Vm) and teicoplanin (Te) by synthesis of pentadepsipeptide peptidoglycan precursors terminating in D-lactate, which replaces D-alanine in the same position of precursors utilized by susceptible enterococci. Cloning and nucleotide sequencing indicated that Tn1546 contains an additional gene, designated vanZ, which confers low-level Te resistance, in the absence of the genes required for pentadepsipeptide synthesis, Analysis of cytoplasmic peptidoglycan precursors, accumulated in the presence of ramoplanin, showed that VanZ-mediated Te resistance does not involve incorporation of a substituent of D-alanine into the precursors.

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页码：87 / 92

页数：6

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