2'-DEOXY-2'-HALONUCLEOTIDES AS ALTERNATE SUBSTRATES AND MECHANISM-BASED INACTIVATORS OF LACTOBACILLUS-LEICHMANNII RIBONUCLEOTIDE REDUCTASE

被引：27

作者：

HARRIS, G ^{[1
]}

ASHLEY, GW ^{[1
]}

ROBINS, MJ ^{[1
]}

TOLMAN, RL ^{[1
]}

STUBBE, J ^{[1
]}

机构：

[1] UNIV WISCONSIN, COLL AGR & LIFE SCI, DEPT BIOCHEM, MADISON, WI 53705 USA

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 07期

关键词：

D O I：

10.1021/bi00381a017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：1895 / 1902

页数：8

共 28 条

[1]

AMES BN, 1960, J BIOL CHEM, V235, P769

[2]

ASHLEY GW, 1986, J BIOL CHEM, V261, P3958

[3] CURRENT IDEAS ON THE CHEMICAL MECHANISM OF RIBONUCLEOTIDE REDUCTASES [J].

ASHLEY, GW ;

STUBBE, J .

PHARMACOLOGY & THERAPEUTICS, 1985, 30 (03) :301-329

[4] MECHANISM OF INACTIVATION OF ESCHERICHIA-COLI RIBONUCLEOTIDE REDUCTASE BY 2'-CHLORO-2'-DEOXYURIDINE 5'-DIPHOSPHATE - EVIDENCE FOR GENERATION OF A 2'-DEOXY-3'-KETONUCLEOTIDE VIA A NET 1,2 HYDROGEN SHIFT [J].

ATOR, MA ;

STUBBE, J .

BIOCHEMISTRY, 1985, 24 (25) :7214-7221

[5]

Blakley R L, 1978, Methods Enzymol, V51, P246, DOI 10.1016/S0076-6879(78)51034-3

[6] SUBSTRATE AND EFFECTOR BINDING TO RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE OF LACTOBACILLUS-LEICHMANNII [J].

CHEN, AK ;

BHAN, A ;

HOPPER, S ;

ABRAMS, R ;

FRANZEN, JS .

BIOCHEMISTRY, 1974, 13 (04) :654-661

[7] NUCLEOSIDES .18. SYNTHESIS OF 2]-FLUOROTHYMIDINE 2]-FLUORODEOXYURIDINE + OTHER 2]-HALOGENO-2]-DEOXY NUCLEOSIDES [J].

CODINGTON, JF ;

FOX, JJ ;

DOERR, IL .

JOURNAL OF ORGANIC CHEMISTRY, 1964, 29 (03) :558-&

[8]

FOLLMANN H, 1971, BIOCHEMISTRY-US, V10, P186

[9] ELECTRON-SPIN RESONANCE STUDIES .33. EVIDENCE FOR HETEROLYTIC AND HOMOLYTIC TRANSFORMATIONS OF RADICALS FROM 1,2-DIOLS AND RELATED COMPOUNDS [J].

GILBERT, BC ;

NORMAN, ROC ;

LARKIN, JP .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1972, (06) :794-&

[10] MECHANISM OF INACTIVATION OF ESCHERICHIA-COLI AND LACTOBACILLUS-LEICHMANNII RIBONUCLEOTIDE REDUCTASES BY 2'-CHLORO-2'-DEOXYNUCLEOTIDES - EVIDENCE FOR GENERATION OF 2-METHYLENE-3(2H)-FURANONE [J].

HARRIS, G ;

ATOR, M ;

STUBBE, J .

BIOCHEMISTRY, 1984, 23 (22) :5214-5225

← 1 2 3 →