PARASITOLOGICAL, SEROLOGICAL, AND CLINICAL-STUDIES OF WUCHERERIA-BANCROFTI IN LIMBE, HAITI

A survey for W. bancrofti in Limbe, Haiti, revealed that 17% (231/1450) had a patient infection. Nearly half of those surveyed harbored < 10 microfilariae (mf)/20 mm3 of finger-prick blood; the median mf density for females and males was 12.4 and 9.5, respectively. Parasitemias occurred as early as age 4. Antibody titers .gtoreq. 1:20 against adult Dipetalonema viteae antigen were observed in 38% of microfilaremic individuals and in 29% of amicrofilaremic individuals. Peak antibody responsiveness (40%) was observed between 5-9 yr of age. In all age groups there was no correlation between mf density and antibody titer. Among the mf carriers, 5.6% had no clinical symptoms. Lymphangitis was a common feature with 14.3% having lymphedema, 8.2% with edema of the lower extremities, and 1.3% reporting episodes of chyluria. Genital involvement among women was rare, but in males 5.4% had genital swelling and 4.5% had hydrocels. Culex quinquefasciatus (Say) was observed to support the complete development of W. bancrofti in Limbe.