ANTIINFLAMMATORY EFFECTS OF ONIONS - INHIBITION OF CHEMOTAXIS OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES BY THIOSULFINATES AND CEPAENES

被引：36

作者：

DORSCH, W

SCHNEIDER, E

BAYER, T

BREU, W

WAGNER, H

机构：

[1] UNIV MUNICH,CHILDRENS HOSP,W-8000 MUNICH 2,GERMANY

[2] UNIV MUNICH,INST PHARMACEUT BIOL,W-8000 MUNICH 2,GERMANY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 92卷 / 01期

关键词：

D O I：

10.1159/000235221

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Seven different synthetic thiosulfinates, and cepaene- and/or thiosulfinate-rich onion extracts were found to inhibit in vitro the chemotaxis of human granulocytes induced by formyl-methionine-leucine-phenylalanine in a dose-dependent manner and at a concentration range of 0.1-100 μM Diphenylthiosulfinate showed the highest activity and was found to be more active than prednisolone. The anti-inflammatory properties of onion extracts are related, at least in part, to the inhibition of inflammatory cell influx by thiosulfinates and cepaenes. © 1990 S. Karger AG, Basel.

引用

页码：39 / 42

页数：4

共 15 条

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