THE INVIVO MICRONUCLEUS ASSAY IN MAMMALIAN BONE-MARROW AND PERIPHERAL-BLOOD - A REPORT OF THE UNITED-STATES-ENVIRONMENTAL-PROTECTION-AGENCY GENE-TOX PROGRAM

被引：402

作者：

MAVOURNIN, KH

BLAKEY, DH

CIMINO, MC

SALAMONE, MF

HEDDLE, JA

机构：

[1] ONTARIO MINIST ENVIRONM, BIOHAZARD LAB, REXDALE M9W 5L1, ONTARIO, CANADA

[2] YORK UNIV, DEPT BIOL, DOWNSVIEW M3J 1P3, ONTARIO, CANADA

[3] HLTH & WELF CANADA, ENVIRONM HLTH DIRECTORATE, BUR CHEM HAZARDS, MUTAGENESIS SECT, OTTAWA K1A 0L2, ONTARIO, CANADA

[4] US EPA, DIV HLTH & ENVIRONM REV TS796, OFF TOX SUBST, WASHINGTON, DC 20460 USA

来源：

MUTATION RESEARCH | 1990年 / 239卷 / 01期

关键词：

Bone marrow; Chromosomal aberrations; in vivo; mammalian; Micronucleus assay; Peripheral blood;

D O I：

10.1016/0165-1110(90)90030-F

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The protocol recommended for the micronucleus assay in mammalian bone marrow has been revised and simplified. The number of sample times has been reduced to one or two, depending upon the dosing protocol. The minimum number of cells to be scored per treatment group has been increased to 20 000 to increase the ability of the assay to detect a doubling of the control micronucleus frequency. Use of both male and female animals is recommended. Scoring of micronuclei in polychromatic erythrocytes of peripheral blood is included as a variation of the bone marrow assay. Published data on chemicals tested by the micronucleus assay have been reviewed and are summarized. © 1990.

引用

页码：29 / 80

页数：52

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