THE DROSOPHILA-MELANOGASTER GENE LETHAL(3)73AH ENCODES A RING FINGER PROTEIN HOMOLOGOUS TO THE ONCOPROTEINS MEL-18 AND BMI-1

被引：21

作者：

IRMINGERFINGER, I ^{[1
]}

NOTHINGER, R ^{[1
]}

机构：

[1] UNIV ZURICH IRCHEL,INST ZOOL,CH-8056 ZURICH,SWITZERLAND

来源：

GENE | 1995年 / 163卷 / 02期

关键词：

LATE PUPAL LETHAL MUTATION; FAT-BODY-SPECIFIC GENE EXPRESSION; OVERLAPPING GENES;

D O I：

10.1016/0378-1119(95)00326-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Drosophila melanogaster (Dm) gene lethal(3)73Ah, essential at the late pupal stage, encodes a protein with a novel Cys-rich sequence motif, typical for ring-finger proteins. Amino-acid sequence comparison revealed a striking homology of the entire lethal(3)73Ah sequence to the gene products of the mammalian oncogenes, mel-18 and bmi-1, and to the zinc-finger-containing N-terminal region of the Dm proteins encoded by the Posterior sex combs and Suppressor two of zeste genes. The lethal(3)73Ah gene is located in a densely transcribed region sharing 3'-untranslated sequences with the adjacent sex-determining gene, transformer. Its transcription is temporally and spatially regulated with maximal expression in adult females. In all stages the mRNA can be localized to the fat body and, in addition, to the ovaries of adult females.

引用

页码：203 / 208

页数：6

共 26 条

[1]

BELOTE JM, 1990, GENETICS, V125, P783

[2] DROSOPHILA GENES POSTERIOR SEX COMBS AND SUPPRESSOR 2 OF ZESTE ENCODE PROTEINS WITH HOMOLOGY TO THE MURINE BMI-1 ONCOGENE [J].

BRUNK, BP ;

MARTIN, EC ;

ADLER, PN .

NATURE, 1991, 353 (6342) :351-353

[3] THE SEX-DETERMINING GENE TRA OF DROSOPHILA - MOLECULAR-CLONING AND TRANSFORMATION STUDIES [J].

BUTLER, B ;

PIRROTTA, V ;

IRMINGERFINGER, I ;

NOTHIGER, R .

EMBO JOURNAL, 1986, 5 (13) :3607-3613

[4] COMPARISON OF THE CONSENSUS SEQUENCE FLANKING TRANSLATIONAL START SITES IN DROSOPHILA AND VERTEBRATES [J].

CAVENER, DR .

NUCLEIC ACIDS RESEARCH, 1987, 15 (04) :1353-1361

[5] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[6] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[7] A NOVEL CYSTEINE-RICH SEQUENCE MOTIF [J].

FREEMONT, PS ;

HANSON, IM ;

TROWSDALE, J .

CELL, 1991, 64 (03) :483-484

[8] THE BMI-1 AND MEL-18 GENE-PRODUCTS DEFINE A NEW FAMILY OF DNA-BINDING PROTEINS INVOLVED IN CELL-PROLIFERATION AND TUMORIGENESIS [J].

GOEBL, MG .

CELL, 1991, 66 (04) :623-623

[9] AN IMPROVED INSITU HYBRIDIZATION METHOD FOR THE DETECTION OF CELLULAR RNAS IN DROSOPHILA TISSUE-SECTIONS AND ITS APPLICATION FOR LOCALIZING TRANSCRIPTS OF THE HOMEOTIC ANTENNAPEDIA GENE-COMPLEX [J].

HAFEN, E ;

LEVINE, M ;

GARBER, RL ;

GEHRING, WJ .

EMBO JOURNAL, 1983, 2 (04) :617-623

[10] NOVEL ZINC FINGER GENE IMPLICATED AS MYC COLLABORATOR BY RETROVIRALLY ACCELERATED LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE [J].

HAUPT, Y ;

ALEXANDER, WS ;

BARRI, G ;

KLINKEN, SP ;

ADAMS, JM .

CELL, 1991, 65 (05) :753-763

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