THE ONCOGENIC POTENTIAL OF AN ACTIVATED HOX-2.4 HOMEOBOX GENE IN MOUSE FIBROBLASTS

被引：73

作者：

ABERDAM, D ^{[1
]}

NEGREANU, V ^{[1
]}

SACHS, L ^{[1
]}

BLATT, C ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT MOLEC GENET & VIROL,IL-76100 REHOVOT,ISRAEL

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 01期

关键词：

D O I：

10.1128/MCB.11.1.554

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.

引用

页码：554 / 557

页数：4

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