ANTIOXIDANT PROPERTIES OF THE ALKALOID BOLDINE IN SYSTEMS UNDERGOING LIPID-PEROXIDATION AND ENZYME INACTIVATION

被引：79

作者：

SPEISKY, H

CASSELS, BK

LISSI, EA

VIDELA, LA

机构：

[1] UNIV CHILE, FAC MED,DEPT CIENCIAS BIOL,UNIDAD BIOQUIM, CASILLA 33052 CORREO 33, SANTIAGO, CHILE

[2] UNIV CHILE, FAC CIENCIAS, DEPT QUIM, SANTIAGO, CHILE

[3] CATHOLIC UNIV CHILE, FAC QUIM, SANTIAGO, CHILE

来源：

BIOCHEMICAL PHARMACOLOGY | 1991年 / 41卷 / 11期

关键词：

D O I：

10.1016/0006-2952(91)90156-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Boldine, in low micromolar concentrations, was able to prevent brain homogenate auto-oxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation of lysozyme. These results are indicative of a high reactivity of boldine towards free radicals. The analysis of the boldine effect as a function of incubation times suggests that a metabolite resulting from the interaction of boldine with free radicals also exhibits antioxidant activity, being more efficient than boldine in brain homogenate auto-oxidation and less efficient in lysozyme protection experiments. This behavior may be accounted for in terms of the relative location of the scavengers needed to afford maximal protection.

引用

页码：1575 / 1581

页数：7

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