CURCUMIN INHIBITS NITRITE-INDUCED METHEMOGLOBIN FORMATION

被引：48

作者：

UNNIKRISHNAN, MK ^{[1
]}

RAO, MNA ^{[1
]}

机构：

[1] COLL PHARMACEUT SCI,DEPT PHARMACEUT CHEM,MANIPAL 576119,KARNATAKA,INDIA

来源：

FEBS LETTERS | 1992年 / 301卷 / 02期

关键词：

CURCUMIN; METHEMOGLOBIN FORMATION INHIBITION; NITRITE-INDUCED METHEMOGLOBIN; ANTIOXIDANT;

D O I：

10.1016/0014-5793(92)81246-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when curcumin is added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of curcumin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.

引用

页码：195 / 196

页数：2

共 7 条

[1] INVOLVEMENT OF PEROXIDE AND SUPEROXIDE IN THE OXIDATION OF HEMOGLOBIN BY NITRITE [J].

DOYLE, MP ;

PICKERING, RA ;

DYKSTRA, RL ;

NELSON, CL ;

BOYER, RF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 105 (01) :127-132

[2]

Elizabeth K, 1990, INT J PHARMACEUT, V58, P237, DOI DOI 10.1016/0378-5173(90)90201-E

[3]

ELIZABETH K, 1989, INT J PHARMACEUT, V57, P173

[4] ANTIOXIDANT ACTIVITY OF CURCUMIN AND RELATED COMPOUNDS [J].

SHARMA, OP .

BIOCHEMICAL PHARMACOLOGY, 1976, 25 (15) :1811-1812

[5] PREVENTION BY 3-N-RIBOSYLURIC ACID OF THE OXIDATION OF BOVINE HEMOGLOBIN BY SODIUM-NITRITE [J].

SMITH, RC ;

NUNN, V .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 232 (01) :348-353

[6] INVOLVEMENT OF SUPEROXIDE ANION IN THE REACTION-MECHANISM OF HEMOGLOBIN OXIDATION BY NITRITE [J].

TOMODA, A ;

TSUJI, A ;

YONEYAMA, Y .

BIOCHEMICAL JOURNAL, 1981, 193 (01) :169-179

[7]

WALLACE WJ, 1982, J BIOL CHEM, V257, P4966

← 1 →