FUNDAMENTALS OF PHOTODYNAMIC THERAPY - CELLULAR AND BIOCHEMICAL ASPECTS

被引：79

作者：

PENNING, LC

DUBBELMAN, TM

机构：

[1] Department of Medical Biochemistry, Sylvius Laboratory, 2300 RA Leiden

来源：

ANTI-CANCER DRUGS | 1994年 / 5卷 / 02期

关键词：

HEMATOPORPHYRIN DERIVATIVE; PHOTOSENSITIZERS; PHOTODYNAMIC THERAPY; CLONOGENICITY; BLADDER TUMOR; CELL DEATH;

D O I：

10.1097/00001813-199404000-00003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy of cancer is based on the photosensitizing ability of dyes which, after administration, are present in a somewhat higher concentration in tumors than in surrounding normal tissue. After light activation of the sensitizer, singlet oxygen and probably oxygen free radicals are formed and consequently all kinds of cellular components are affected. This review focuses on cellular and biochemical aspects of photodynamic therapy. Both damage to different cellular targets and cellular responses after photodynamic treatment are discussed.

引用

页码：139 / 146

页数：8

共 98 条

[1]

AGARWAL ML, 1991, CANCER RES, V51, P5993

[2]

APPLEGATE LA, 1991, CANCER RES, V51, P974

[3] PHOTOSENSITIZED DESTRUCTION OF HUMAN BLADDER-CARCINOMA CELLS TREATED WITH CHLORIN E6-CONJUGATED MICROSPHERES [J].