CHARACTERIZATION OF THE ALPHA(1)-ADRENOCEPTORS OF THE RAT PROSTATE-GLAND

被引：14

作者：

COULDWELL, C ^{[1
]}

JACKSON, A ^{[1
]}

OBRIEN, H ^{[1
]}

CHESSWILLIAMS, R ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,WESTERN BANK,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 10期

关键词：

D O I：

10.1111/j.2042-7158.1993.tb05623.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The alpha1-adrenoceptor-mediated responses of the rat prostate to phenylephrine have been examined in-vitro. Phenylephrine induced concentration-dependent contractions of the isolated prostate gland which were antagonized by WB4101 (1-30 nM). Schild plot analysis of the antagonism yielded a straight line with a slope not significantly different from unity. The pK(B) value of 9.2 was similar to that obtained for WB4101 on the rat vas deferens (9.4) but was greater than that obtained on the rat spleen (8.4). Chloroethylclonidine depressed responses to phenylephrine of the rat spleen but not the prostate or the vas deferens. These results indicate that the rat prostate gland possesses a typical alpha1A-adrenoceptor similar to that found in the vas deferens.

引用

页码：922 / 924

页数：3

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