CU/ZN SUPEROXIDE DISMUTASE-LIKE IMMUNOREACTIVITY IN LEWY BODY-LIKE INCLUSIONS OF SPORADIC AMYOTROPHIC-LATERAL-SCLEROSIS

被引：129

作者：

SHIBATA, N

HIRANO, A

KOBAYASHI, M

SASAKI, S

KATO, T

MATSUMOTO, S

SHIOZAWA, Z

KOMORI, T

IKEMOTO, A

UMAHARA, T

ASAYAMA, K

机构：

[1] TOKYO WOMENS MED COLL, DEPT NEUROL, SHINJUKU KU, TOKYO 162, JAPAN

[2] MONTEFIORE MED CTR, DEPT PATHOL, DIV NEUROPATHOL, BLUESTONE LAB, BRONX, NY 10467 USA

[3] YAMAGATA UNIV, SCH MED, DEPT INTERNAL MED, YAMAGATA 99023, JAPAN

[4] KITANO HOSP, DEPT NEUROL, KITA KU, OSAKA 530, JAPAN

[5] YAMANASHI MED COLL, DEPT INTERNAL MED, TAMAHO 40938, YAMANASHI, JAPAN

[6] YAMANASHI MED COLL, DEPT PEDIAT, TAMAHO 40938, YAMANASHI, JAPAN

[7] TOKYO MED COLL, DEPT GERIATR, SHINJUKU KU, TOKYO 160, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 179卷 / 1-2期

关键词：

AMYOTROPHIC LATERAL SCLEROSIS; SUPEROXIDE DISMUTASE; IMMUNOHISTOCHEMISTRY; LEWY BODY-LIKE INCLUSION; SKEIN-LIKE INCLUSION; BUNINA BODY;

D O I：

10.1016/0304-3940(94)90956-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cu/Zn superoxide dismutase (SOD)-like immunoreactivity (LI) was found within Lewy body-like inclusions (LBIs) in the spinal cords of patients with sporadic amyotrophic lateral sclerosis (ALS) by using an antibody to human Cu/ZnSOD. LBIs were detected in the anterior horn cells in 10 of 20 patients with sporadic ALS. in each of these patients, 7 to 60% of LBIs showed Cu/ZnSOD-LI. No Cu/ZnSOD-LI was detected in intact neurons and glia in the 20 ALS patients, as well as in these cells in 10 normal control individuals. The skein-like inclusions and Bunina bodies. which were found in all of the 20 ALS cases, showed no Cu/ZnSOD-LI. Thus, Cu/ZnSOD appears to play roles in the production and/or degradation process of LBIs.

引用

页码：149 / 152

页数：4

共 15 条

[1] JOINT PURIFICATION OF MANGANO AND CUPROZINC SUPEROXIDE DISMUTASES FROM A SINGLE SOURCE - A SIMPLIFIED METHOD [J].