HUMAN AND RAT CHROMOSOMAL LOCALIZATION OF 2 GENES FOR 6-PHOSPHOFRUCTO-2-KINASE FRUCTOSE-2,6-BISPHOSPHATASE BY ANALYSIS OF SOMATIC-CELL HYBRIDS AND INSITU HYBRIDIZATION

被引：27

作者：

HILLIKER, CE

DARVILLE, MI

ALY, MS

CHIKRI, M

SZPIRER, C

MARYNEN, P

ROUSSEAU, GG

CASSIMAN, JJ

机构：

[1] CATHOLIC UNIV LOUVAIN,SCH MED,HORMONE & METAB RES UNIT,B-1200 BRUSSELS,BELGIUM

[2] INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM

[3] UNIV LIBRE BRUXELLES,DEPT BIOL MOLEC,B-1640 RHODE ST GENESE,BELGIUM

来源：

GENOMICS | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90174-D

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two genes encoding 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase were localized in human and rat chromosomes. PFKFB1 (previously PFRX), which encodes the liver and muscle isozymes, was assigned to Xq22-q31 in the rat and to Xq27-q28 in the human by in situ hybridization using probes generated by the polymerase chain reaction. PFKFB2, which encodes the heart isozyme of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, was assigned to chromosome 13 in the rat and to chromosome 1 in the human by hybridization of DNA from somatic cell hybrids. By in situ hybridization, this gene was localized to the regions 13q24-25 in the rat and 1q31 in the human. © 1991.

引用

页码：867 / 873

页数：7

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