1ST-DERIVATIVE UV SPECTROPHOTOMETRIC AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF SOME THIAZIDE DIURETICS IN THE PRESENCE OF THEIR PHOTODECOMPOSITION PRODUCTS

被引：31

作者：

ULVI, V

KESKIHYNNILA, H

机构：

[1] Department of Pharmacy, University of Helsinki, FIN-00014 Helsinki

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1994年 / 12卷 / 07期

关键词：

THIAZIDE DIURETICS; PHOTODECOMPOSITION; ANALYSIS; 1ST-DERIVATIVE UV SPECTROPHOTOMETRY; HPLC;

D O I：

10.1016/0731-7085(94)E0014-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ethanolic solutions of three thiazide diuretics, chlorothiazide, hydrochlorothiazide and trichlormethiazide, were irradiated with a high-pressure mercury lamp. The products were isolated and their first-derivative UV spectra in ethanol were recorded and compared to those of the parent compounds. The determination of the parent compounds in the presence of the decomposition products was carried out at wavelengths near 220 nm using the zero-crossing technique. Three reversed-phase HPLC methods were also developed for the analysis of the parent compounds. In parallel analyses of the reaction mixtures a good correlation was achieved between these two methods in the determination of hydrochlorothiazide and trichlormethiazide while there was greater variation in the results of chlorothiazide.

引用

页码：917 / 922

页数：6

共 5 条

[1] DETERMINATION OF SULFACETAMIDE, SULFADIMIDINE OR SULFATHIOUREA IN THE PRESENCE OF THEIR DEGRADATION PRODUCTS USING 1ST DERIVATIVE SPECTROPHOTOMETRY [J].