PATHOGENESIS OF FOOT-AND-MOUTH-DISEASE IN SWINE, STUDIED BY IN-SITU HYBRIDIZATION

被引：26

作者：

BROWN, CC ^{[1
]}

OLANDER, HJ ^{[1
]}

MEYER, RF ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT VET PATHOL,DAVIS,CA 95616

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 1995年 / 113卷 / 01期

关键词：

D O I：

10.1016/S0021-9975(05)80068-4

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Eight 7-month-old pigs were inoculated intradermally with 10(3) plaque-forming units of foot-and-mouth disease virus, type O, and killed 24, 48, 72, or 96 h later. Numerous tissues from each animal were collected and examined histopathologically and by in-situ hybridization to determine the presence of virus and its correlation with lesion development. The probe for in-situ hybridization was a biotinylated 500-base negative-sense transcription product corresponding to a portion of the gene encoding polymerase. With this technique, virus was shown to be widely disseminated in all epidermal tissues, regardless of histologically apparent cellular disruption. (C) 1995 Academic Press Limited

引用

页码：51 / 58

页数：8

共 6 条

[1]

BROWN CC, 1992, CAN J VET RES, V56, P189

[2] A PRELIMINARY-STUDY OF THE PATHOGENESIS OF FOOT-AND-MOUTH-DISEASE VIRUS USING INSITU HYBRIDIZATION [J].

BROWN, CC ;

OLANDER, HJ ;

MEYER, RF .

VETERINARY PATHOLOGY, 1991, 28 (03) :216-222

[3]

FRENKEL HS, 1949, AM J VET RES, V10, P142

[4] MICROSCOPIC SKIN LESIONS IN CATTLE WITH FOOT-AND-MOUTH DISEASE [J].

GAILIUNAS, P .

ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG, 1968, 25 (02) :188-+

[5]

GAILIUNAS P, 1966, J BACTERIOL, V9, P2333

[6]

YILMA T, 1980, AM J VET RES, V41, P1537

← 1 →