PROGNOSTIC FACTORS IN BLADDER-CANCER - A PATHOLOGICAL, IMMUNOHISTOCHEMICAL, AND DNA FLOW-CYTOMETRIC STUDY

被引：11

作者：

LOPEZBELTRAN, A

CROGHAN, GA

CROGHAN, I

MATILLA, A

GAETA, JF

机构：

[1] UNIV MALAGA,ANAT PATHOL UNIT,MALAGA,SPAIN

[2] SUNY COLL BUFFALO,BUFFALO,NY

[3] ROSWELL PK CANC INST,DEPT PATHOL,BUFFALO,NY

[4] ROSWELL PK CANC INST,DEPT CANC EPIDEMIOL,BUFFALO,NY

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 1994年 / 102卷 / 01期

关键词：

BLADDER CANCER SURVIVAL; DNA PLOIDY; IMMUNOHISTOCHEMISTRY; PATHOLOGY; TRANSITIONAL CELL CARCINOMA;

D O I：

10.1093/ajcp/102.1.109

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pathologic grade and stage, immunohistochemical analysis of eight cell and tumor markers, and DNA ploidy were studied in 36 cases of bladder cancer to determine the features of value in assessment of patients' survival. Tumors of high grade and advanced stage correlated with DNA aneuploidy, whereas low grade and early stage correlated with DNA diploidy when simultaneously evaluated with survival. In addition, blood group isoantigen A correlated with DNA ploidy in deceased patients, whereas blood group isoantigen H and oncogene-related protein p21 correlatedwell with DNA ploidy in surviving patients. Despite the relatively small number of cases studied, these results suggest that pathologic grade and stage and immunohistochemical analysis of blood group isoantigens A and H and oncogene-related protein p21 hold additional value in the prediction of bladder cancer survival when evaluated simultaneously with DNA ploidy.-

引用

页码：109 / 114

页数：6

共 55 条

[1] PROGNOSTIC INDEXES IN TRANSITIONAL CELL-CARCINOMA OF THE BLADDER [J].

ABEL, PD .

BRITISH JOURNAL OF UROLOGY, 1988, 62 (02) :103-109

[2]

[Anonymous], STATISTICAL PACKAGE

[3]

ARMITAGE P, 1971, STATISTICAL METHODS

[4] IMMUNOHISTOCHEMICAL EXPRESSION OF KERATIN PROTEINS IN URINARY-BLADDER CARCINOMA [J].

ASAMOTO, M ;

FUKUSHIMA, S ;

TATEMOTO, Y ;

YAMADA, K ;

FUKUI, S ;

MORI, M .

PATHOLOGY RESEARCH AND PRACTICE, 1989, 184 (02) :194-201

[5]

BAISCH H, 1975, 1ST INT S PULS CYT, P68

[6]

BERGSTROM E, 1987, UROL RES, V15, P199

[7]

BLASCO E, 1988, CANCER, V64, P1094

[8] THE VALUE OF MORPHOMETRY AND DNA FLOW-CYTOMETRY IN ADDITION TO CLASSIC PROGNOSTICATORS IN SUPERFICIAL URINARY-BLADDER CARCINOMA [J].

BLOMJOUS, ECM ;

SCHIPPER, NW ;

BAAK, JPA ;

VOS, W ;

DEVOOGT, HJ ;

MEIJER, CJLM .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1989, 91 (03) :243-248

[9] FLOW-CYTOMETRY AS A PREDICTOR OF RESPONSE AND PROGRESSION IN PATIENTS WITH SUPERFICIAL BLADDER-CANCER TREATED WITH BACILLUS CALMETTE-GUERIN [J].

BRETTON, PR ;

HERR, HW ;

KIMMEL, M ;

FAIR, WR ;

WHITMORE, WF ;

MELAMED, MR .

JOURNAL OF UROLOGY, 1989, 141 (06) :1332-1336

[10]

CARATERO C, 1990, EUR UROL, V18, P145

← 1 2 3 4 5 6 →