GENETIC-CONTROL OF IMMUNE-RESPONSE AND DISEASE SUSCEPTIBILITY BY THE HLA-DQ GENE

被引：18

作者：

NISHIMURA, Y ^{[1
]}

KAMIKAWAJI, N ^{[1
]}

FUJISAWA, K ^{[1
]}

YOSHIZUMI, H ^{[1
]}

YASUNAMI, M ^{[1
]}

KIMURA, A ^{[1
]}

SASAZUKI, T ^{[1
]}

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,3-1-1 MAIDASHI,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

RESEARCH IN IMMUNOLOGY | 1991年 / 142卷 / 5-6期

关键词：

HLA; IMMUNOGENETICS; IMMUNOSUPPRESSION; LYMPHOCYTE-T; ANTIGEN PRESENTATION; IMMUNE RESPONSE GENE; DISEASE SUSCEPTIBILITY;

D O I：

10.1016/0923-2494(91)90048-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The particular alleles of the HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ-restricted and antigen-specific CD4+ suppressor/inducer T cells, because (1) a statistically significant association and linkage between low immune responsiveness to the natural antigens and the HLA-DQ gene were observed; (2) antigen-specific CD4+ T cells restricted by the DQ molecules encoded for by the HLA-DQ allele associated with low responsiveness were evidenced in many low responders; and (3) anti-HLA-DQ mAb restored the immune response to natural antigens, in some low responders. This HLA-DQ-controlled polymorphism of immune response to the natural antigens may account for the association between HLA-DQ alleles and organ-specific autoimmune diseases.

引用

页码：459 / 466

页数：8

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