AXONAL FLOW BLOCKADE INDUCES ALPHA-CGRP MESSENGER-RNA EXPRESSION IN RAT MOTONEURONS

被引：19

作者：

KATOH, K

TOHYAMA, M

NOGUCHI, K

SENBA, E

机构：

[1] OSAKA UNIV,SCH MED,DEPT ANAT,OSAKA,JAPAN

[2] WAKAYAMA MED COLL,DEPT ANAT & NEUROBIOL,WAKAYAMA 640,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 599卷 / 01期

关键词：

AXONAL FLOW; VINBLASTINE; ALPHA-CGRP; BETA-CGRP; MESSENGER RNA MOTONEURON; RAT;

D O I：

10.1016/0006-8993(92)90864-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Axonal flow of motoneurons was blocked in the sciatic nerve by the application of vinblastine at a low concentration (100 muM) not considered likely to cause axonal degeneration. The number of motoneurons expressing a-calcitonin gene-related peptide (CGRP) mRNA was significantly increased by vinblastine application, while the expression of beta-CGRP mRNA was not influenced. These findings suggest that the synthesis of these two peptides is differentially regulated and that alpha-CGRP mRNA is possibly down-regulated by unknown factor(s) which normally undergo retrograde transport from the periphery.

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页码：153 / 157

页数：5

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